Stem Cell Factor (SCF)- The c-kit ligandHematopoiesis is governed by a number of cytokines that promote the survival, proliferation, and differentiation of hematopoietic stem cells and progenitor cells. Stem cell factor (SCF; also known as kit ligand, mast cell growth factor, or steel factor) is a hematopoietic cytokine that triggers its biologic effects by binding to its receptor, c-kit.
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IMGENEX has now p73 phosphospecific antibodyThe p53 family member, p73, also known as tumor protein 73 (TP73) has been recently identified as a structural and functional homolog of the tumor suppressor protein p53. For more details read out the article:
Cytoskeleton-the cellular scaffoldThe cytoskeleton is a network of fibers throughout the cell's cytoplasm that helps the cell maintain its shape and gives support to the cell. It is a cellular scaffolding or skeleton contained within the cytoplasm, present in both eukaryotes and prokaryotes. For more details read out the article:
Faces of DARPP-32: Master Signaling Mediator in the Brain?As a major target for dopamine-activated adenylyl cyclase and protein kinase A in the striatum, DARPP-32 plays a central role in regulating the efficacy of dopaminergic neurotransmission and can act either as a phosphatase or kinase inhibitor in a contextually dependent manner. For more detail read out the article:
Transcriptional Factors And RegulatorsAll the cellular processes in living cells such as growth, development, morphogenesis and cellular differentiation are a product of gene expression programs involving complicated transcriptional regulation of several genes. This process of transcriptional regulation is tightly controlled and coordinated by proteins called transcriptional regulators.
New FOXP3and#916;2 (Exon 2 Deleted) Specific AntibodyFOXP3 is a master regulator of immune homeostasis expressed specifically in CD4+ CD25+ T regulatory cells controlling their growth, development and function and generally accepted to be expressed in both mouse and human CD4+ CD25+ regulatory T cells. Although the emergence of regulatory T-cells and the role of FoxP3 as a critical player in their development holds great promise for the development
Improved RNA interference kits launched by ImgenexRNA interference (RNAi) is the process of mRNA degradation that is induced by double-stranded RNA in a sequence-specific manner. RNAi has been observed in all eukaryotes, from yeast to mammals. The RNAi pathway is thought to be an ancient mechanism for protecting the host and its genome against viruses and rogue genetic elements that use double-stranded RNA (dsRNA) in their life cycles. For more d
Fundamental Immunology, Basic Immunology and Allergy ImmunologyImmunology is a broad branch of biomedical science that covers the study of all aspects of the immune system in all organisms. The immune system is the body's defense against infectious organisms and other invaders. Through a series of steps called the immune response, the immune system attacks organisms and substances that invade our systems and cause disease. For more details read out the follow
Regulatory T Cells (Treg)Early development and differentiation of nascent T cells inside the thymus is a complex and remarkable mechanism. These types of T-cells require a different strategy to tame their autoimmune potential. One of many immunotolerance mechanisms that immune system has developed to distinguish between self and non-self antigens is regulatory T cells or Tregs. For more details read out the article:
ATM (Ataxia Telangiectasia Mutated) Antibodies from ImgenexATM, the gene product mutated in the cancer susceptibility syndrome ataxia-telangiectasia, is related to proteins involved in DNA repair and cell-cycle control. In undamaged cells it is present as a dimer or oligomer molecule in which the kinase domain is silent because associated with the FAT region of another ATM monomer. For more information about ATM read out the given article:
Actin Antibody Available in Imgenex nowActin is a ubiquitous protein involved in the formation of filaments that are major components of the cytoskeleton. It is the monomeric subunit of microfilaments, one of the three major components of the cytoskeleton, and of thin filaments which are part of the contractile apparatus in muscle cells. For more details read out the article:
Toll-Like Receptor(TLR) : Unique Antibody from ImgenexToll-like Receptor (TLR) family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs are evolutionarily conserved and their congeners have been found in insects, plants, and mammals. For more details read out the following article:
